mdlbear: Wild turkey hen close-up (turkey)
[personal profile] mdlbear

Today is Isaac Newton's Birthday, so I'd like to start by wishing you all a very Heavy Newtonmas. I am thankful for...

  • Friction, and in particular socks with grippy bottoms for wearing around the house.
  • Gravity, without which those socks wouldn't work. (Neither would a lot of other things, of course. I'm also looking for a little levity, and not finding nearly enough.)
  • The reason for the season -- axial tilt. Also, having just about the right amount of it. (Uranus has way too much!)
  • Calculus -- integral, differential, and lambda.
  • Number systems in which infinitesimals are, um..., well-defined. I guess you can't say "real", can you?
  • Choice.
  • Having slightly less mass than I did last year. (Very slightly, but I'll take what I can get.) Good drugs.

52/299-300: Crackling

Dec. 24th, 2025 05:39
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[personal profile] rejectomorph
We just had quite a spectacular storm for the holiday evening. It woke me from my nap with loud nearby thunder and copious, wind-whipped rain lashing my window. At times the wind was so loud I couldn't distinguish it from the peals of thunder that must have been following those flashes of lightning. The lights flickered a few times, but we never lost power. Lying in bed I imagined water seeping under the doorsills, but when I finally got up the floors remained dry. There were actually two bouts of storminess, so I think we were in the eye for several minutes, with the second bout being the less intense.

It's gotten very quiet now, with just occasional drops of rain hitting the vent pipes and sending tinny sounds through the room. There is sure to be more rain overnight, and it's supposed to last through Friday. There is apparently snow in the mountains, and some flooding in parts of the valley, and a high wind warning remains in effect, but I suspect that the real spectacle is over. In a while I'm going to fix my delayed dinner, and I'll probably be ready to get back to sleep by dawn.

Oh, if Claus was flying over Buttehole County when that storm hit, I'm afraid there'll be no more presents this year. There's no way that sleigh could have escaped a lightning strike, and the cadavers of the elf and his reindeer are probably being munched by carrion eaters right now. Too bad they didn't fall near my apartment. I'd gladly risk a soaking to avoid doing my own cooking. Mmm, crispy fat elf skin! Better than cracklings!

Best of Reviews 2025, Part Two

Dec. 25th, 2025 07:00
[syndicated profile] smartbitches_feed

Posted by Amanda

NB: This week, we’re taking a look back at 2025. We’ve got a week of best-of posts to share, with reviews, cover snark, sales, and more. We hope you enjoy revisiting our archives, and most of all, we wish you and yours a wonderful holiday and a happy new year – with all the very best of reading.

We’re counting down the best of our 2025 reviews, which I’m sure you’re all curious about. Time to reveal our top five reviews of this year. I’d love to know what your predictions are!

Let’s get into it!

Serial Killer Games
A | BN | K | AB
5. Serial Killer Games by Kate Posey (April 28)

Review by Lara

Grade: A

I went into this book totally oblivious. I didn’t even know what genre it was. I had been drawn in by the slick cover and the vague blurb. This is 100% the way I recommend you approach this novel. If you’ve read a few of my reviews and you tend to like the books I like, I recommend stopping here.

 

Maid for Each Other
A | BN | K | AB
4. Maid for Each Other by Lynn Painter (July 17)

Review by Lara

Grade: A-

This is an average length book at 368 pages. But it flew past in the blink of an eye. If I were to make a reading recommendation, I would say block off half a day and forbid anyone from interrupting you, then dive into this book and just revel in it.

I really really enjoyed this book. I wanted it to be so much longer so that I could immerse myself in more of their banter. I happily recommend this book to the Bitchery.

 

Rules for Ruin
A | BN | K | AB
3. Rules for Ruin by Mimi Matthews (May 19)

Review by Lara

Grade: A

This is my first Bad Decisions Book Club of 2025. Sleep became a distant memory with this book. For context, I have a newborn. I had the opportunity to sleep, but chose not to because this book was much more important. It is also the start of a series and it’s a series I’m now very excited about!

If you too would like to join the Bad Decisions Book Club and immerse yourself in a tale of vulnerability and courage, with excellent dialogue, emotional depth, and very clever characters, then this is the book for you.

 

Variation
A | BN
2. Variation by Rebecca Yarros (February 13)

Review by Elyse

Grade: C

Variation is a tough book to review. On one hand, I found myself putting aside things that I needed to get done in order to keep reading it, but on the other, I found the frequent “surprise” reveals in the plot to be so frequent that sometimes they felt silly.

The result was the plot tension was kind of up-down-up-down and made me feel a little seasick. Everyone in this book could have helped themselves a lot by just talking to each other.

I think a lot of readers looking for high emotion or high drama romance will like that up-down feeling, though. It just wasn’t for me, in part because of the uneven tension, and because I think some of the plot twists were a little over the top. That said, I was enthralled by the detailed professional lives of the characters, and it left me searching for more ballet-related romance fiction.

 

Great Big Beautiful Life
A | BN | K | AB
1. Great Big Beautiful Life by Emily Henry (April 21)

Review by Lara

Grade: A

I dithered for a week before starting this book. I had it in my possession, but couldn’t get past the first page. I’m not sure if this is unique to me, but when I’m really looking forward to something, it’s very difficult for me to start it. Then, one morning I bit the bullet and pushed through to page two. From there, I tore through the book, snatching reading time wherever I could until I finished it this evening.

Afterward, I think I felt every emotion there is to feel.

I loved this novel. As much as it put me through the emotional wringer, the quality of the writing forced me to keep reading it and I am so very glad that I did. I think the one caution I would add is that this is more women’s fiction than it is contemporary romance. Regardless of genre specifics, Great Big Beautiful Life echoed for days after I finished it. I’m not sure I’ll ever revisit it, but I will certainly remember it.

What did you think of our most popular reviews? Were there some you hoped to see in the top five? Let us know in the comments!

ysabetwordsmith: Damask smiling over their shoulder (polychrome)
[personal profile] ysabetwordsmith
This poem came out of the May 7, 2025 Poetry Fishbowl. It was inspired by prompts from [personal profile] siliconshaman and [personal profile] wyld_dandelyon. It also fills the "Crisis" square in my 5-1-24 card for the Superhero Bingo fest. This poem has been sponsored by a pool with [personal profile] fuzzyred. It belongs to the Big One and Kraken threads of the Polychrome Heroics series.

Read more... )

So tired

Dec. 24th, 2025 23:01
legalmoose: (Default)
[personal profile] legalmoose
And tomorrow will be an early morning. But we played games until far too late this evening. Holding off on stockings til the morning. Non-food stuff is sorted, but I need to split up the candy.

Good run to get comics, and lunch at the local Italian restaurant next to the comic shop. Brief nap mid-afternoon, but not quite enough. This is why I took Monday off as well, so I can catch up on sleep once they head out.

One more sleep 'til Xmas.

Another beautiful winter day.

Dec. 24th, 2025 17:55
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[personal profile] ranunculus
I spent the whole day fixing up the road from last night's  2 inches of rain.  Lots of digging out ditches for the first two hours and then three hours of work on the culvert near the main gate.  Dad put the 30" (?, it is big) culvert in around 1965.   At that time the neighbor took a bulldozer into the creek and cleaned out all of the vegetation.  No one would be allowed to do that these days, but back then no one noticed.  As time went by willow, blackberry and cottonwood trees grew up, dramatically slowing the flow of water below the culvert.  Above the culvert silt slowly began building up. And up.  Then the willow and cottonwoods started to fall.   They weren't sick, they were just old.   That blocked the exit of the culvert  where even more silt built up.  About eight years ago I realized there was a crisis with the culvert.  Water had to first go down to reach the culvert, then up on the other side to exit.  Donald and I spent two days fighting our way down into the stream with a chainsaw and clearing out dead wood.  It helped, some.  Since then I've been down there several times, each time clearing more.  Today I mostly cleared willow that had regrown into the creek, once again making it impassable.   Last week a huge very dead old cottonwood finally fell on the road right over the culvert.  We have been watching that tree just waiting for a windstorm to jiggle it a little.  
Read more... )

Yesterday's walk in pics.

Dec. 24th, 2025 17:28
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[personal profile] ranunculus
Yesterday's trip up Red Barn Creek to work on trail maintenance was lovely.  Kinda wet, but lovely. 
You may remember that I went off with some of the folks from the Grace Hudson Museum ( https://www.gracehudsonmuseum.org/ ) to pick Dogbane, sometimes called Indian Hemp. At the time I didn't post a picture of the plant. Here is a clump of Dogbane growing -in- the creek.  There is a small green bit of grass coming up through the clump. This is the right time to harvest these plants, the stems will need to dry before use, but the plant is dormant. 

Victoria 2025

Dec. 25th, 2025 00:45
[syndicated profile] matthew_feed

Posted by Matthew McQuilkin

[Adapted from working draft of my third "Christmastime travelogue" of the year, set to be send out next weekend.]

Monday, December 22: The Victoria Clipper

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An overnight trip 11 months in the making! Longer than that, even; I just can't remember when we first started discussing taking an overnight trip to Victoria during the holiday season—I just know that Shobhit and Laney and I, all booked the Victoria Clipper, and a hotel, as far back as late January. By March, Laney coming along kind of fell through, and for a while I thought it would just be Shobhit and me. Shobhit kept trying to convince me to cancel the trip outright just to save money, which was very annoying. By June, Alexia—pictured with us, above—expressed interest in coming along, and within another couple of months she had her own ticket booked on the same Clipper ride, and her own room in the same hotel. This made me happy because Shobhit couldn't keep trying to convince me to cancel it. Side note: by the time the trip was done, he was openly commenting on how much fun it was and how glad he was that we all went. Go figure.

I have now been to Victoria eight times over the past 40 years, five of those over the last 20 years, and this is only the second time I have ever gone via the Clipper. I last went with Barbara, 25 years ago, in 2000. It was on that boat ride that I learned I can get seasick, and on this trip I went out of my way to make sure I had Dramamine on hand. It always works, so that's good.



Gingerbread Showcase Victoria

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The Victoria Clipper has one daily sailing each direction between Seattle and Victoria. The northbound ride leaves at 8 a.m. and arrives at 11 a.m. This gave us a good five hours until the official check-in time of our hotel, and three hours before our hotel let us check in early.

In the meantime, in addition to the one major event that was the whole impetus for going to Victoria this time of year (I'll get to that momentarily), I naturally made a list of any and all holiday-season activities available to do in Victoria while we were there. And turns out, Victoria has its own gingerbread event each year, a Habitat for Humanity benefit called Gingerbread Showcase. This happens in the lobby at the Hotel Grand Pacific in Victoria, which was literally across the street from the ferry terminal, so it was an easy first destination.

Much like Gingerbread Village in Seattle's Sheraton Hotel lobby, people line up to take a look at all the "gingerbread creations" (as they term it here)—the key difference is that the Seattle event tends to have four huge creations made by large teams of people; the Victoria event has thirty-three creations, one of the rules of which is that they must be at least 18" tall. Which is to say, these are much smaller—but not necessarily less elaborate or impressive. We were truly stunned by a lot of them. The above house wasn't even the most impressive; it was simply one of my favorites, as I do love gingergothic architecture.



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There were maybe three different sections where people lined up in the Hotel Grand Pacific lobby, to observe around 11 of these "gingerbread creations" each. And yes, the above absolutely stunning piece is a "gingerbread creation," made entirely of edible materials—also one of the three rules (the other being that it must fit on the 2' x 2' base provided). I had to restrain myself from reaching out and touching that fabric, it looked so real. This one was called The Heart of a Home, and on the informational sign we could reach about each creation, the artist for this one noted that what she was most proud of was the basket and quilt. I'd be the most proud of that too!

Some other fabulous creations included a bit of Whoville, a shipping container complex, a gingerbread co-op, and just about all of Middle Earth; some other fabulous details included a marshmallow llama and marshmallow sheep, a cookie campfire, and shredded wheat as bales of hay. I'm barely scratching the surface here, and I took 64 shots at this stop alone.



Fairmont Empress Hotel Lobby

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Victoria is a ridiculously walkable city, with countless points of interest within blocks of each other. The Hotel Grand Pacific was also all of three blocks or so from our hotel; and Victoria's famous Fairmont Empress Hotel is about two and a half blocks away, just in a slightly different direction. We still needed time to kill before we could check in at our hotel, and as all the lists I found of holiday season activities in Victoria tended to mention the decor in the lobby at the Empress, we went over there too. The above shot is looking up at a large Christmas Tree in one of the many lobby sections of the hotel; click here to see it from above, on the second level.

It was in that lobby section that, while we were there, hotel staff set out cookies and hot chocolate, free for the taking. You know Shobhit and I are all about that shit! And these were high quality on both counts, complete with fresh whipped cream, marshmallows and thick crunched chocolate pieces. Naturally I loaded my cup with all of it.



Helms Inn Victoria

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Helms Inn, a pretty nondescript looking hotel from the outside, was a lodging choice Shobhit and I landed on after a pretty protracted period of research and deliberation back in January. Alexia booked her room there for little reason other than so we would all be at the same hotel. And in the end, all three of us were so happy with our stay there that we're going to make a note of it as our first choice of booking the next time we visit Victoria. It's very centrally located, has spotless and very comfortable rooms, and is quite reasonably priced. Ironically given that Shobhit and I always look for this when we travel but it wasn't really needed here for just a one-night stay, our room did have a full kitchenette. The lady at the front desk was beyond nice and helpful, but then what else should we have expected?—she's Canadian.

Best of all, though, was how delightfully festive their lobby was for Christmas. The shot above was by far my favorite photo I took in there, though. Anyway, we went in first at around 12:15 and of course our rooms were not available; they let us lighten our load and store our bags in a locked closet, though. We came back again two hours later and by then both our rooms were available to check in.

Side note: Shobhit kept saying "Helms Inn" wrong. He would constantly say either "Hell's Inn," or a couple of times, "Helm's Deep." Pretty far off on both counts!



Festival of Trees Victoria

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Victoria also has their own Festival of Trees, which, similar to the Seattle Festival of Trees benefiting Seattle Children's Hospital, benefits BC Children's Hospital. The Victoria festival features a whole lot more trees—dozens, some years apparently around 100—perhaps because there's more space for them at the Bay Centre shopping center than we have in Seattle's Fairmont Olympic Hotel lobby (to be fair, this lobby is much prettier than a shopping mall). Each tree is very much themed by their sponsor, and I got a particular kick out of this "Cookie Monster" tree, sponsored by RE/MAX.



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A good example of the many sponsors who really leaned in with the services they provide as a theme for their tree: this is a detail shot of the tree made by Urban Smiles Victoria, a local dentist located in downtown Victoria. It even had a fun, tooth plushie as the tree topper.



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An adorably tiny couple of tea tables on the Christmas Tree skirt, beneath the tree sponsored by Pendray Inn & Tea House.



The Magic of Christmas at Butchart Gardens

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It's the reason for the season! Or at least, the primary reason for this trip: "The Magic of Christmas" at Butchart Gardens, a botanical garden that is beautiful to visit any time of year, but when I heard they deck it out in Christmas lights, I wanted to see it.

They sell packages where you can ride a shuttle bus straight there and back, but there was only one departure time and it didn't work very well for us. So, even though it takes a full hour to get out there, the city bus has far more flexibility with tons of buses out there and back all day—and a day pass on the bus costs only $6 CAD. (If you're not local, your only option is to get cash, which is a little annoying but whatever; this was the only thing we needed Canadian cash for, and Shobhit simply went to a nearby currency exchange to get $18 worth of Canadian money. And then? The machine on the bus out there was broken so we didn't even have to pay in that direction! We only had to pay the $3 to ride the bus back.)

It was pretty rainy in Victoria Monday evening, but we all brought umbrellas and it was fine. The gardens were spectacular, and we all agreed that it was well worth going out to, even on a one-hour bus in the rain. We caught the 3:05 bus at the stop across the street from our hotel; arrived at Butchart Gardens at about 4:15; spent about 65 minutes under our umbrellas in the gardens; waited a solid half hour for a bus headed back downtown to arrive; and got to our next destination at 6:30. We might have spent more time browsing the gift shop and the like, but given the wet and cold weather we were ready to head back. Between departure and return, the Butchart Gardens excursion took us a total of about three and a half hours.



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Among many other great displays, one of the biggest delights at Butchart Gardens was the collection of 12 different displays scattered throughout, representing The Twelve Days of Christmas—the above shot representing by far my favorite of them, the "Three French Hens," drinking coffee and eating croissants by the Eiffel Tower. I did make a dedicated photo album just for these twelve displays, in countdown order, should you want to see them all.



Lights of Wonder - Victoria

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Upon our return downtown from Butchart Gardens, we got off a few stops early, disembarking right on the block where "Lights of Wonder" is located, at Centennial Square. They basically pack the entire square with brilliant light displays, including a brightly lit—and functional—Ferris wheel. And it was free! So, you can bet your ass I wanted to ride it: I took the above shot from the top. Between the Ferris Wheel at Holiday Magic at the Washington State Fairgrounds and this one, I rode two holiday-season Ferris Wheels in the space of only three days.

It was very cold and breezy riding this thing but I'm still super glad we did it. Afterward, Shobhit used Yelp to find us a nearby Mexican place for dinner called Maiiz, and it was so spectacularly authentic that, along with our hotel, I will be making a note to seek that place out again whenever we next visit Victoria. If any of you might go there soon, put it on your list!



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Did I mention the British Columbia Parliament Buildings are beautifully lit on winter nights? They've been outlining the buildings with lights since 1897, to commemorate the Diamond Jubilee of Queen Victoria, and have been lit nightly throughout the year since 1965. They add red and green colors to the lights during the holiday season.



Tuesday, December 23: Miniature World - Victoria

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This one was also part of the original plan, one of the few major points of interest in Victoria that I still had never done: Miniature World, with a wide array of themes among its many miniature displays. I used the above shot because Alexia can be seen at upper left for scale. She was happy to go with me while Shobhit, who usually has little to no interest in museums, roamed around the city on his own, I should note, though, that this little holiday display was at the front desk and most of the dioramas inside are exponentially larger.

The museum has a few more war-destroyed cities than I needed, but still had a pretty diverse array of themes, from historic Canadian cityscapes to fairy tales to the circus to an array of elaborate dollhouses. In some cases a display kind of combined the cityscape with the dollhouse, offering a cross section of a large building: check out the couple of naked women in this one! (There's also a naked man in a bathtub, but alas, he's sitting so we don't get to see his butt.)



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Alexia took this fantastic shot of me, wearing my new candy cane earrings I found at a nearby shop, at the quite-delicious Murchie's Tea & Coffee. We were at a shop selling all-Canadian-made merchandise about a block away, where Alexia purchased a calendar, and when she asked the cashier if he knew of a good place to get pastries, he did a very convincing deadpan when he said, "Are you kidding?" and then acted kind of shocked we did not know about Murchie's. So we went over there, and it did not disappoint. Shobhit and I shared a delicious Greek sandwich; and I had a super tasty "Christmas Tea Latte" (the drink Alexia also ordered), along with lemon tea shortbread cookies.



Black Ball Ferry to Port Angeles

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You may notice the header here does not say "Victoria Clipper back to Seattle." Why? Because our return trip on the Clipper got canceled! The northbound trip from Seattle in the morning was canceled too—no sailings at all on Tuesday, due to an "unforeseen mechanical issue beyond our control," so said the email notice Shobhit happened to see before I was even out of bed Tuesday morning.

Funny that this should happen the day after our hotel desk woman informed us that a bunch of the BC Ferries—a different ferry agency—had been canceled on Monday due to high winds. At that time, we were just grateful we had made it on the Clipper, and as of yet had no indication that our itinerary would be affected. Turned out ours was affected by something totally unrelated.

The Clipper offered us three options: we could rebook our return trip for another day (this option being presented to us the day before Christmas Eve—ha!); we could cancel our return trip for a 50% refund and make alternative travel arrangements (not very easily done when we got all the way up there without any vehicles); or we could take up the Clipper's offer of re-booking us on the Black Ball Ferry scheduled to leave for Port Angeles at 4:00—an hour earlier than the Clipper was originally scheduled to leave—with shuttle buses waiting to drive us two and a half hours back to Seattle from there. We took that last option. The Black Ball Ferry left at about 4:20, roughly 20 minutes delayed; the buses got us to Seattle at about 9:20, a good 90 minutes later than the Clipper was originally scheduled to arrive. So, what originally should have been a three-hour, point-to-point boat ride turned into a five-hour boat-and-bus journey.

But, whatever: I used the time on the bus efficiently, working on editing photos and my draft of this very email. Plus I got some great photos of Victoria at dusk as this other ferry pulled away. You can see from the shot above that we got a beautiful sunset as we sailed away. The whole trip was so much fun we still all felt it was well worth it, even considering both the weather and the travel inconveniences.

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[posted 4:45pm]
siderea: (Default)
[personal profile] siderea
2025 Dec 24: ScienceDaily [press release?]: "Scientists reverse Alzheimer’s in mice and restore memory":
By examining both human Alzheimer's brain tissue and multiple preclinical mouse models, the team identified a key biological failure at the center of the disease. They found that the brain's inability to maintain normal levels of a critical cellular energy molecule called NAD+ plays a major role in driving Alzheimer's. Importantly, maintaining proper NAD+ balance was shown to not only prevent the disease but also reverse it in experimental models.
WARNING WARNING WARNING: Yes, there are OTC supplements for tinkering with your NAD+, but they are apparently/allegedly CARCINOGENIC (cause CANCER) at typical doses. DO NOT run out and do something stupid. Tinkering with your whole-body cellular metabolism has some gnarly failure modes. From this article:
Why This Approach Differs From Supplements

Dr. Pieper cautioned against confusing this strategy with over the counter NAD+-precursors. He noted that such supplements have been shown in animal studies to raise NAD+ to dangerously high levels that promote cancer. The method used in this research relies instead on P7C3-A20, a pharmacologic agent that helps cells maintain healthy NAD+ balance during extreme stress, without pushing levels beyond their normal range.
Continuing from the article:
NAD+ levels naturally decline throughout the body, including the brain, as people age. When NAD+ drops too low, cells lose the ability to carry out essential processes needed for normal function and survival. The researchers discovered that this decline is far more severe in the brains of people with Alzheimer's. The same pattern was seen in mouse models of the disease.

[...]

Amyloid and tau abnormalities are among the earliest and most significant features of Alzheimer's. In both mouse models, these mutations led to widespread brain damage that closely mirrors the human disease. This included breakdown of the blood-brain barrier, damage to nerve fibers, chronic inflammation, reduced formation of new neurons in the hippocampus, weakened communication between brain cells, and extensive oxidative damage. The mice also developed severe memory and cognitive problems similar to those seen in people with Alzheimer's.

[...]

This approach built on the group's earlier work published in Proceeding of the National Academy of Sciences USA, which showed that restoring NAD+ balance led to both structural and functional recovery after severe, long-lasting traumatic brain injury. In the current study, the researchers used a well-characterized pharmacologic compound called P7C3-A20, developed in the Pieper laboratory, to restore NAD+ balance.

The results were striking. Preserving NAD+ balance protected mice from developing Alzheimer's, but even more surprising was what happened when treatment began after the disease was already advanced. In those cases, restoring NAD+ balance allowed the brain to repair the major pathological damage caused by the genetic mutations.

Both mouse models showed complete recovery of cognitive function. This recovery was also reflected in blood tests, which showed normalized levels of phosphorylated tau 217, a recently approved clinical biomarker used to diagnose Alzheimer's in people. These findings provided strong evidence of disease reversal and highlighted a potential biomarker for future human trials.
Note, potential conflict of interest: the head of the lab, Dr Pieper, above, has a serious commercial interest in this proving out:
The technology is currently being commercialized by Glengary Brain Health, a Cleveland-based company co-founded by Dr. Pieper.
The actual research article:

2025 Dec 22: Cell Reports Medicine [peer-reviewed scientific journal]: Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain by Kalyani Chaubey et al. (+35 other authors!):
Abstract:

Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.
Full text here: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1

(no subject)

Dec. 24th, 2025 18:31
flemmings: (Default)
[personal profile] flemmings
I believed the forecast that said rain Monday night and thus was disheartened to find snow on the rooftops Tuesday morning. Slidy slush, not quite as bad as two weeks ago. Had to wear new boots which, even with thick socks and gel bunion pads, hurt to walk in. But had last physio session till the new year and bought a turkey dinner at Farm Boy while temps rose to above freezing.

Today was sun and old boots. Debated walking in shoes but luckily good sense prevailed.  There's still a lot of ice at street corners and laneways, and lower back having conniptions for no good reason,  unless boots count as same. But went out for Pauper's Christmas dinner anyway. Turkey was dry, and there was too much of it, but the root veg, mash, and stuffing were excellent as ever. But filling, very filling. My stomach is shrinking, not that it affects my weight at all.

Finished Our Lady of Mysterious Ailments, next installment in Huchu's Edinburgh Nights series. Was a bit of a downer to start cause Ropa can never catch a break, but very satisfying by the end. Shall read on when I'm assured I can get to the library without pain.

Still with Petty Treason, the Sarah Tolerance Regency mystery, and a Dr Priestley, The Bloody Tower, which I just know will end up hinging on obscure ballistical knowledge. Dr Priestleys almost always tend to John Dickson Carr levels of odd and unlikely murder methods.

After that who knows? Friday is supposed to be unspeakable and I will be indoors for a while. What I wanted to do was reread Little, Big which should be on the shelves in the front bedroom-- I can see it there clearly-- but I combed them this morning, back screaming like a banshee, moving many ancient volumes back and forth and filling a bag with To Be Donateds, but it's nowhere to be found. 

Victory, Somehow

Dec. 24th, 2025 19:12
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[personal profile] soemand
Against all logic—and an alarming amount of gingerbread‑house candy—we actually got our little one to sleep tonight. Even the excitement buzzing off her about tomorrow couldn’t keep her up forever. The house is finally quiet, the tree is glowing, and our sugar‑fueled elf is out cold. A small Christmas miracle.
venta: (Default)
[personal profile] venta
Aye up.

My visits to write LJ entries seem these days to be occasional, in every sense. But it's Christmas, and I know a couple of you look for me at Christmas, so here we are.

To cover the important traditional points: I'm at my parents' house, we've got the fire in, I've snuggled up the pigs in blankets, Dad and I have pints of beer. More to the point, it is proper brown beer that tastes brown, which is vanishingly hard to find these days. Rockin' Rudolph made by - of all people - Greene King. Who'd have thought it?

Today, we had a delightfully throwback experience: lift tree in from garden*, adorn tree with fairy lights, plug in fairy lights...

Nowt.

Not a sausage. )

Also, as usual: I've written some Christmas puzzles. If you'd like them, drop me a line.

Yuletide insta-rec!

Dec. 24th, 2025 17:51
kass: omg wtf yuletide! (wtf (yuletide))
[personal profile] kass
I got such a lovely story for Yuletide! It's extremely charming, all the voices feel spot-on, it made me laugh out loud, and it reminds me of so much of what I love about this canon in all its forms.

Wrong on the Internet (1159 words) by Anonymous
Chapters: 1/1
Fandom: Murderbot (TV)
Rating: General Audiences
Warnings: No Archive Warnings Apply
Characters: Murderbot (Murderbot Diaries), Dr. Gurathin (Murderbot Diaries), Dr. Mensah (Murderbot Diaries), Dr. Ratthi (Murderbot Diaries)
Summary:

The SecUnit didn't go to its repair pod last night. Gurathin is determined to find out why.

ysabetwordsmith: Text says New Year Resolutions on notebook (resolutions)
[personal profile] ysabetwordsmith posting in [community profile] goals_on_dw
TRY NEW THINGS THIS YEAR: 28 NEW YEAR’S RESOLUTION IDEAS

The best New Year’s goals are all about getting out of your comfort zone or routine! Even if you love setting resolutions that are practical—like saving money or decluttering—it’s great to dedicate yourself to trying something new this year. Here’s some inspiration for your 2026 goals!


Mixing fun or adventurous goals into your list along with practical ones makes it easier to accomplish things.

Offline on the Edge of the Bay

Dec. 24th, 2025 17:57
soemand: (Default)
[personal profile] soemand
At the in‑laws’ place, the outside world barely exists—one flickering bar of service, if I’m lucky. The Bay of Fundy stretches out in front of us, grey and endless, the tide doing its slow, ancient breathing.

Inside, the little one is on high alert, glued to the window, waiting for a certain jolly, oversized visitor to make his grand entrance. Every creak is a possibility. Every gust of wind is a sign.
Disconnected, quiet, and oddly perfect.

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bill_schubert

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