Happy Thingie.

Dec. 25th, 2025 00:41
curiosity: A full moon in a star-filled sky over a winding highway. (Picto: Road and Sky)
[personal profile] curiosity posting in [community profile] holiday_wishes
Y'all, it has been a year.

I'm Cat. Mid-40's AuDHD/C-PTSD who keeps on truckin'. Keeping it short and sweet because my spoons are in the negative.

1.) My bestie [personal profile] lilliane posted her list earlier this month. Check it out. Her brain surgery is on the 29th so if you have good wishes or prayers, she's taking those too.

2.) I don't have any lists or fancy wishes. I'm in need of Amazon or Kroger gift cards. That's it. I'm looking at a new year with no way to afford health insurance so whatever I can put in to getting basics is more cash I can put towards my medication.

3.) Be excellent to each other. Do your daily clicks.

That's it. Be safe, be merry, don't let the world grind you down.

Peace.

52/299-300: Crackling

Dec. 24th, 2025 05:39
rejectomorph: (Default)
[personal profile] rejectomorph
We just had quite a spectacular storm for the holiday evening. It woke me from my nap with loud nearby thunder and copious, wind-whipped rain lashing my window. At times the wind was so loud I couldn't distinguish it from the peals of thunder that must have been following those flashes of lightning. The lights flickered a few times, but we never lost power. Lying in bed I imagined water seeping under the doorsills, but when I finally got up the floors remained dry. There were actually two bouts of storminess, so I think we were in the eye for several minutes, with the second bout being the less intense.

It's gotten very quiet now, with just occasional drops of rain hitting the vent pipes and sending tinny sounds through the room. There is sure to be more rain overnight, and it's supposed to last through Friday. There is apparently snow in the mountains, and some flooding in parts of the valley, and a high wind warning remains in effect, but I suspect that the real spectacle is over. In a while I'm going to fix my delayed dinner, and I'll probably be ready to get back to sleep by dawn.

Oh, if Claus was flying over Buttehole County when that storm hit, I'm afraid there'll be no more presents this year. There's no way that sleigh could have escaped a lightning strike, and the cadavers of the elf and his reindeer are probably being munched by carrion eaters right now. Too bad they didn't fall near my apartment. I'd gladly risk a soaking to avoid doing my own cooking. Mmm, crispy fat elf skin! Better than cracklings!
alias_sqbr: (up and down)
[personal profile] alias_sqbr
During the family Christmas Zoom call Mum asked if I had any recs for historical computer games in which the protagonist does not commit acts of violence. When I asked what kinds of gameplay she enjoyed she just said "nothing too hard".

So here's what I came up with after exploring the historical and education tags on steam, if anyone has any recs or anti-recs please let me know!
Read more... )
ysabetwordsmith: Damask smiling over their shoulder (polychrome)
[personal profile] ysabetwordsmith
This poem came out of the May 7, 2025 Poetry Fishbowl. It was inspired by prompts from [personal profile] siliconshaman and [personal profile] wyld_dandelyon. It also fills the "Crisis" square in my 5-1-24 card for the Superhero Bingo fest. This poem has been sponsored by a pool with [personal profile] fuzzyred. It belongs to the Big One and Kraken threads of the Polychrome Heroics series.

Read more... )

Coulda, Shoulda, but Didn't

Dec. 24th, 2025 21:31
fauxklore: (Default)
[personal profile] fauxklore
I am not doing brilliantly at getting things done. I still need to finish holiday cards, for example. And, in particular, I need to find where I put the stamps I am sure I have.

I also need to finish finalizing some travel plans. There are tickets to various events that I need to buy, too.

And I am nearly out of clean clothes.

I could, theoretically, be getting some of this done tonight. But, I think I am going to prioritize the book I’m in the middle of.

Another beautiful winter day.

Dec. 24th, 2025 17:55
ranunculus: (Default)
[personal profile] ranunculus
I spent the whole day fixing up the road from last night's  2 inches of rain.  Lots of digging out ditches for the first two hours and then three hours of work on the culvert near the main gate.  Dad put the 30" (?, it is big) culvert in around 1965.   At that time the neighbor took a bulldozer into the creek and cleaned out all of the vegetation.  No one would be allowed to do that these days, but back then no one noticed.  As time went by willow, blackberry and cottonwood trees grew up, dramatically slowing the flow of water below the culvert.  Above the culvert silt slowly began building up. And up.  Then the willow and cottonwoods started to fall.   They weren't sick, they were just old.   That blocked the exit of the culvert  where even more silt built up.  About eight years ago I realized there was a crisis with the culvert.  Water had to first go down to reach the culvert, then up on the other side to exit.  Donald and I spent two days fighting our way down into the stream with a chainsaw and clearing out dead wood.  It helped, some.  Since then I've been down there several times, each time clearing more.  Today I mostly cleared willow that had regrown into the creek, once again making it impassable.   Last week a huge very dead old cottonwood finally fell on the road right over the culvert.  We have been watching that tree just waiting for a windstorm to jiggle it a little.  
Read more... )

Yesterday's walk in pics.

Dec. 24th, 2025 17:28
ranunculus: (Default)
[personal profile] ranunculus
Yesterday's trip up Red Barn Creek to work on trail maintenance was lovely.  Kinda wet, but lovely. 
You may remember that I went off with some of the folks from the Grace Hudson Museum ( https://www.gracehudsonmuseum.org/ ) to pick Dogbane, sometimes called Indian Hemp. At the time I didn't post a picture of the plant. Here is a clump of Dogbane growing -in- the creek.  There is a small green bit of grass coming up through the clump. This is the right time to harvest these plants, the stems will need to dry before use, but the plant is dormant. 
siderea: (Default)
[personal profile] siderea
2025 Dec 24: ScienceDaily [press release?]: "Scientists reverse Alzheimer’s in mice and restore memory":
By examining both human Alzheimer's brain tissue and multiple preclinical mouse models, the team identified a key biological failure at the center of the disease. They found that the brain's inability to maintain normal levels of a critical cellular energy molecule called NAD+ plays a major role in driving Alzheimer's. Importantly, maintaining proper NAD+ balance was shown to not only prevent the disease but also reverse it in experimental models.
WARNING WARNING WARNING: Yes, there are OTC supplements for tinkering with your NAD+, but they are apparently/allegedly CARCINOGENIC (cause CANCER) at typical doses. DO NOT run out and do something stupid. Tinkering with your whole-body cellular metabolism has some gnarly failure modes. From this article:
Why This Approach Differs From Supplements

Dr. Pieper cautioned against confusing this strategy with over the counter NAD+-precursors. He noted that such supplements have been shown in animal studies to raise NAD+ to dangerously high levels that promote cancer. The method used in this research relies instead on P7C3-A20, a pharmacologic agent that helps cells maintain healthy NAD+ balance during extreme stress, without pushing levels beyond their normal range.
Continuing from the article:
NAD+ levels naturally decline throughout the body, including the brain, as people age. When NAD+ drops too low, cells lose the ability to carry out essential processes needed for normal function and survival. The researchers discovered that this decline is far more severe in the brains of people with Alzheimer's. The same pattern was seen in mouse models of the disease.

[...]

Amyloid and tau abnormalities are among the earliest and most significant features of Alzheimer's. In both mouse models, these mutations led to widespread brain damage that closely mirrors the human disease. This included breakdown of the blood-brain barrier, damage to nerve fibers, chronic inflammation, reduced formation of new neurons in the hippocampus, weakened communication between brain cells, and extensive oxidative damage. The mice also developed severe memory and cognitive problems similar to those seen in people with Alzheimer's.

[...]

This approach built on the group's earlier work published in Proceeding of the National Academy of Sciences USA, which showed that restoring NAD+ balance led to both structural and functional recovery after severe, long-lasting traumatic brain injury. In the current study, the researchers used a well-characterized pharmacologic compound called P7C3-A20, developed in the Pieper laboratory, to restore NAD+ balance.

The results were striking. Preserving NAD+ balance protected mice from developing Alzheimer's, but even more surprising was what happened when treatment began after the disease was already advanced. In those cases, restoring NAD+ balance allowed the brain to repair the major pathological damage caused by the genetic mutations.

Both mouse models showed complete recovery of cognitive function. This recovery was also reflected in blood tests, which showed normalized levels of phosphorylated tau 217, a recently approved clinical biomarker used to diagnose Alzheimer's in people. These findings provided strong evidence of disease reversal and highlighted a potential biomarker for future human trials.
Note, potential conflict of interest: the head of the lab, Dr Pieper, above, has a serious commercial interest in this proving out:
The technology is currently being commercialized by Glengary Brain Health, a Cleveland-based company co-founded by Dr. Pieper.
The actual research article:

2025 Dec 22: Cell Reports Medicine [peer-reviewed scientific journal]: Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain by Kalyani Chaubey et al. (+35 other authors!):
Abstract:

Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.
Full text here: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1

Yuletide insta-rec!

Dec. 24th, 2025 17:51
kass: omg wtf yuletide! (wtf (yuletide))
[personal profile] kass
I got such a lovely story for Yuletide! It's extremely charming, all the voices feel spot-on, it made me laugh out loud, and it reminds me of so much of what I love about this canon in all its forms.

Wrong on the Internet (1159 words) by Anonymous
Chapters: 1/1
Fandom: Murderbot (TV)
Rating: General Audiences
Warnings: No Archive Warnings Apply
Characters: Murderbot (Murderbot Diaries), Dr. Gurathin (Murderbot Diaries), Dr. Mensah (Murderbot Diaries), Dr. Ratthi (Murderbot Diaries)
Summary:

The SecUnit didn't go to its repair pod last night. Gurathin is determined to find out why.

ysabetwordsmith: Text says New Year Resolutions on notebook (resolutions)
[personal profile] ysabetwordsmith posting in [community profile] goals_on_dw
TRY NEW THINGS THIS YEAR: 28 NEW YEAR’S RESOLUTION IDEAS

The best New Year’s goals are all about getting out of your comfort zone or routine! Even if you love setting resolutions that are practical—like saving money or decluttering—it’s great to dedicate yourself to trying something new this year. Here’s some inspiration for your 2026 goals!


Mixing fun or adventurous goals into your list along with practical ones makes it easier to accomplish things.

Food

Dec. 24th, 2025 13:48
ysabetwordsmith: Cartoon of me in Wordsmith persona (Default)
[personal profile] ysabetwordsmith
What you eat could decide the planet’s future

What we put on our plates may matter more for the climate than we realize. Researchers found that most people, especially in wealthy countries, are exceeding a “food emissions budget” needed to keep global warming below 2°C. Beef alone accounts for nearly half of food-related emissions in Canada. Small changes—less waste, smaller portions, and fewer steaks—could add up to a big climate win.

Read more... )

Birdfeeding

Dec. 24th, 2025 13:38
ysabetwordsmith: Cartoon of me in Wordsmith persona (Default)
[personal profile] ysabetwordsmith
Today is partly cloudy and mild.

I fed the birds.  I've seen a mixed flock of sparrows and house finches.

I put out water for the birds.

EDIT 12/24/25 -- We hacked up most of the remaining brushpile in the parking lot, and some of the older one by the driveway, feeding those into the chipper.

EDIT 12/24/25 -- We moved the new mulch to the mulch pile.

EDIT 12/24/25 -- I did a bit of work around the patio.  As it is getting dark, I am done for the night.

A Japanese Comedy of Genders

Dec. 24th, 2025 17:56
[syndicated profile] alpennia_feed

Posted by Heather Rose Jones

Wednesday, December 24, 2025 - 09:00

Fiction isn't necessarily a good guide to how a culture thinks about sex and gender--indeed, in some cases social anxieties are worked out in fiction in ways that would not be tolerated in real life--but it can be a space where we see the culture thinking about the subject. This medieval Japanese tale gets even more convoluted than the most extreme of Shakespeare's cross-gender plots.

Major category: 
Full citation: 

Pflugfelder, Gregory M. 1992. “Strange Fates: Sex, Gender, and Sexuality in Torikaebaya Monogatari” in Monumenta Nipponica Vol. 47, No. 3 (Autumn, 1992), pp. 347-368.

This article explores the relationship between physiological sex, social gender, and sexuality (in the sense of sexual interactions) within a 12th century Japanese fictional work. The basic plot (as I’ve assembled it from various parts of the discussion – so I can’t guarantee complete accuracy) is as follows:

  • Two children, one physiologically female and one physiologically male exhibit behavior and interests that don’t align with their expected genders.
  • After some resistance, their parents agree to raise them as the genders that align with their behavior, not with their physiology.
  • The two are socially successful as adults in their behavioral genders, although the mismatch between sex and gender is kept a secret.
  • Himegimi (presenting as a man) marries but keeps the relationship non-sexual although he has romantic feelings for his wife as well as for other women.
  • Himegimi has a close male friend, Saishō, who initiates (what he believes to be) homosexual erotics. Himegimi is not interested. In the course of this, Saishō discovers Himegimi’s biological sex, at which he rapes Himegimi (putatively due to uncontrollable desire) resulting in pregnancy.
  • Himegimi can no longer maintain a male social role and is sequestered by Saishō and pressured to take up a female presentation. After the birth, Himegimi abandons the child and flees.
  • The other sibling, Wakagimi, has been living as a woman sequestered in the women’s quarters. She is indifferent to male attempts to seduce her but enjoys a sexual relationship with the princess she serves as companion to and gets her pregnant.
  • When Himegimi disappears, Wakagimi decides she must go after, but cannot do so in a female role and so takes up a masculine social role.
  • From then on, the two siblings continue in the gender roles that now align with their physiological sex. The various marriage arrangements get sorted out somehow with this new alignment.

Keeping in mind that this is a fictional narrative, the authors discusses various observations about how sex, gender, and sexuality are treated within the tale, as well as noting other ways in which these factors have interacted in fictional and historic narratives.

The tale may be a reworking of an earlier version and is clearly set in a “historic past” relative to the date of composition. This has unknown consequences for determining whether it reflects social attitudes of the composition date, however the gender roles as depicted do align with 12th century court culture. The authors discusses various translations and scholarly studies of the work that introduce modern interpretive frameworks that are more judgmental about the situation than the original text is. Within the text, the siblings’ situation is potentially embarrassing because it’s unusual, not because of the sex/gender elements. A parallel is created with secondary characters who are similarly “unusual” due to their parentage, and whose difference is similarly kept a secret.

The story presents several factors as contributing to gender identity: internal behavioral and temperamental factors (i.e., “behaving like” a boy or girl), which can be modified by personal pragmatic choice (which happens later in the tale, though motivated by external events), fate or destiny affecting birth characteristics (the cause of the siblings’ behavioral preferences is ascribed to a tengu taking revenge for a wrong done in a previous incarnation), and socialization or habit (even after changing gender presentation later in the story, the two siblings retain some attributes of their prior identities due to habit, while in other ways they seamlessly adopt the behaviors of their public gender). Essential factors in establishing and maintaining a gender identity are the clothing and grooming habits assigned to the relevant gender, as well as being granted appropriate ritual signifiers by their parents, such as names and gendered ceremonies.

Behavioral gender is depicted as simultaneously deriving from innate features (their childhood preferences), but also being an automatic consequence of inhabiting a gendered role. When Himegimi is secluded during pregnancy and changes to a female presentation, this is accompanied by the appearance of stereotypically feminine mannerisms and behaviors, as if these were an automatic consequence of putting on the costume.

This is not a story about sexual or gender confusion. The siblings’ childhood behaviors are not ascribed to any physical abnormality. And when they inhabit their various gender roles, they inhabit them fully, not only aligned with social expectations, but exemplars of the role. The only exception being when it comes to aspects of sexual performance where anatomy becomes a factor.

The article critiques earlier studies of the narrative that try to shoehorn it into modern western gender and sexuality frameworks. Although claimed by modern Japanese homosexual movements as an early example of homosexual literature, the situation is both more complicated and simpler. Rather than being subversive or decadent, the tale is strikingly conservative and normative.

The article then explores other stories with similar themes. Another 12th century tale (possibly influenced by this one) involves a physiologically female child raised as a boy due to divine instruction. The character succeeds socially as a man, attains high rank, marries a woman, but then switches to a completely feminine presentation, eventually becoming empress. As in the previous story, although there is misalignment between physiological sex and gender identity during part of the story, the gender performance in each case is aligned with social expectations. This contrasts with mythological and fictional stories involving partial or complete cross-dressing that isn’t aligned with the public gender identity. In these cases the cross-gender performance is usually temporary and to provide the character with empowerment (and primarily involve women adopting male signifiers). In other cases, this sort of overt gender-crossing is presented for humorous purposes. While the preceding involve unambiguous sex (physiology) but ambiguous gender (performance), medical and historic literature includes cases of ambiguous sex (generally interpretable as intersex, from a modern framework) but an unambiguous performance of a specific gender. The author found no narratives in which sexual ambiguity was combined with gender ambiguity.

The sexuality dynamics within the story are complicated and tricky to judge from within the story’s own ethical/moral basis, and later scholarship has often interpreted them from anachronistic frameworks. As the author notes, “If ‘homosexuality’ is taken to mean sexual relations between two males/men or two females/women, each cognizant of the other’s sex and gender, then ‘homosexuality’ does not exist in the world of Torikaebaya.” However there are erotics between people of the same sex and between people of the same gender, but not both at the same time. Himegimi is frequently involved in same-(physiological)-sex relations while in male gender. Wakagimi is not, as gender-segregation practices meant that she did not socialize with physiolocial men. Himegimi has an arranged marriage to a woman (same sex, different gender) but keeps the relationship platonic (presumably to avoid detection). Himegimi is attracted to a number of other women. These relationships involve the formulas and rituals of a sexual relationship without the sex acts. (In an echo of what I call the “convenient twin brother” motif, several of these women later have sexual relationships with Wakagimi after he takes up a masculine gender, and don’t notice the difference.) All these female partners believe themselves to be in a cross-gender relationship, although the reader of the tale knows them to be same-sex.

Somewhat in contrast, Wakagimi attracts the erotic attention of various men (cross-gender, same-sex), but refuses them. It isn’t clear whether this is Wakagimi avoiding a same-sex relationship or following the mores for a virtuous woman. The question is further confused by Wakagimi’s sexual relationship with the princess (cross-sex, same-gender) in which the princess is apparently naïve enough not to realize what’s going on. A similarly complicated situation occurs when Saishō, still enamored of Himegimi, sees male-presenting Wakagimi and pursues him believing him to be male-presenting Himegimi. That is, Saishō believes the encounter to be cross-sex, same-gender, while Wakagimi understands it as same-sex, same-gender. Same-gender desire is an inherent part of the cultural context. Saishō is initially attracted to male-presenting Himegimi and initiates a sexual encounter under that understanding—one which Himegimi tries to reject. (It strikes me that the protagonists both resist male same-gender interactions. Himegimi refrains from female same-gender sex, but Wakagimi does not. It feels like there are some gendered undercurrents going on, but I’m not confident enough to put interpretation on it. The author makes similar speculations about cultural attitudes toward male versus female desire.)

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